Avicor at BIO 2019- Philadelphia, PA (June, 3-6 2019)

Avidin’s CEO László Puskás and Klára Kitajka is participating at BIO 2019 https://convention.bio.org/ to access to global biotech and pharma One-on-One Partnering and for unparalleled networking opportunities with 16,000+ attendees from 74 countries. Avicor’s main focus is to find partners for its diagnostics product development, special interest in those developed for specific sample amplification of pathogen nucleic acids in the ...

Electron paramagnetic resonance spectroscopic studies of the electron transfer reaction of Hantzsch ester and a pyrylium salt

Sebők-Nagy K, Rózsár D, L. G. Puskás LG, Balázs Á and Páli T Abstract The oxidation of Hantzsch ester by a pyrylium cation takes place via electron–proton–electron transfer. The reaction was investigated with EPR spectroscopy using TEMPO and DMPO for inhibition and spin trapping, respectively, of the radicals appearing during the reaction. The present in-depth EPR study of the radical reactions of ...

Services

_Hit discovery _ Our screening capacity is app. 5000 interaction studies weekly. _Target identification _ Our target discovery services are based on high throughput screening assays based on biochemical array or protein-small molecule interaction. We apply 2 different technologies: 1) proprietary surface modification technology developed at AVICOR, where target proteins specifically interact with small molecules on a surface. Using this technology our ...

Avicor granted with Research Development and Innovation grant

The most serious and currently incurable chronic pulmonary disease besides lung cancer is COPD (chronic obstructive pulmonary disease), which is also a national disease in Hungary, registering 15-16 thousand of new patients a year, with an estimated total number of patients over 600 000.

KFI-16 grant (KFI_16-1-2017-0105)

Development of a series of specific nucleic acid enrichment products for sensitive pathogens detection In conventional microbiological diagnostics, the presence of an infectious agent and its antibiotic resistance is detected by a conventional propagation process, which is a slow and non-sensitive. The consortium is planning to produce a series of reagents that can specially enrich clinical or environmental specimens. A …

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Synthesis and Cytoprotective Characterization of 8-Hydroxyquinoline Betti Products

Kanizsai I, Madácsi R, Hackler L Jr, Gyuris M, Szebeni GJ, Huzián O, Puskás LG. Abstract The 8-hydroxyquinoline pharmacophore scaffold has been shown to possess a range of activities as metal chelation, enzyme inhibition, cytotoxicity, and cytoprotection. Based on our previous findings we set out to optimize the scaffold for cytoprotective activity for its potential application in central nervous system ...

Decoding DNA labels by melting curve analysis using real-time PCR

Balog JA, Fehér LZ, Puskás LG. Abstract Synthetic DNA has been used as an authentication code for a diverse number of applications. However, existing decoding approaches are based on either DNA sequencing or the determination of DNA length variations. Here, we present a simple alternative protocol for labeling different objects using a small number of short DNA sequences that differ ...

The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity in Vitro and in Vivo

Hackler L Jr, Ózsvári B, Gyuris M, Sipos P, Fábián G, Molnár E, Marton A, Faragó N, Mihály J, Nagy LI, Szénási T, Diron A, Párducz Á, Kanizsai I, Puskás LG. Abstract C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 was mediated by affecting multiple ...

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

Demjén A, Gyuris M, Wölfling J, Puskás LG, Kanizsai I. Abstract 5-Aminopyrazole-4-carbonitrile and ethyl 5-aminopyrazole-4-carboxylate, as potential trifunctional building blocks are introduced in a facile, chemo- and regioselective multicomponent assembly of imidazo[1,2-b]pyrazoles via the Groebke–Blackburn–Bienaymé reaction (GBB reaction). Besides the synthetic elaboration of a green-compatible isocyanide-based access in three-component mode, we describe an operationally simple, one-pot two-step GBB protocol for ...