Technology

Avi-LinkTM attachment chemistry

Avicor has developed a proprietary attachment chemistry that does not require a specific functional group, and can be applied with a wide range of small drug-like molecules. The immobilisation surface is pre-treated, then reacted with special functionalized silane derivatives; washed and dried and further reacted with different types of functional groups.
We currently use this technology for the production of affinity columns and chemical microarrays.

Drawbacks of existing attachment technologies

Until today the most widespread approach for attaching small drug-like molecules to glass, involves the use of a so-called tag or linker arm: a functional group that chemically reacts with groups on the surface. This method ensures that all compounds will be immobilised to the surface but has 2 major drawbacks:

  1. The compounds have to contain the linker arm, this often means that they have to be resynthesised.
  2. All molecules are attached to the surface in an identical conformation and expose the same side of the molecule for interaction with a protein. Practically this requires you to have a pre-knowledge about the active center of the molecule to prevent you from destroying it's activity.